The long-term consequences of maternal polyI:C exposure

Polyinosinic:polycytidylic acid (PolyI:C) is an immunostimulant that simulates viral infections. Like viruses, it does not see to cross the blood placental barrier but activates the maternal immune system by stimulating the TLR3 receptor (which is found on several immune cells, such as B-cells, macrophages and dendritic cells). Components of the maternal immune system, such as interleukin-6 and others are known to cross the blood placental barrier to reach the foetal brain. Interleukins are known to activate microglia (the brain’s immune system) and during development can cause, what is known as a cytokine… Read More