Publications

Links to our research group’s publications can be found below and on Bart’s Google Scholar profile.

2018 Publications

Xu H, Wang J, Zhang K, Zhao M, Ellenbroek BA, Shao F and Wang W (2018) Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice. Psychoneuroendocrinology 388: 92-101.

Kidwell M and Ellenbroek BA (2018) Heart and Soul: Heart Rate Variability and Major depression. Behav Pharmacol 29: 152-164.

Brox BW and Ellenbroek BA (2017) A genetic reduction in the serotonin transporter differentially influences MDMA and heroin induced behaviours. Psychopharmacol (in press).

Ellenbroek BA and Wang W (2018) The Translational Umbrella – A novel approach to the study of the biological basis of mental health. OBM Neurobiology (in press).

2017 Publications

Ellenbroek BA and Sengul HK (2017) Autism Spectrum Disorders: Autonomic alterations with a special focus on the heart. Heart and Mind 1: e780 -630.

Borroni E, Bohrmann B, Grueninger F, Prinssen E, Nave S, Loetscher H, Chinta SJ, Rajagopalan S, Rane A, Siddiqui A, Ellenbroek BA, Messer J, Pähler A, Andersen JK, Wyler R, Cesura AM (2017) Sembragiline: a novel, selective monoamine oxidase type B inhibitor for the treatment of Alzheimer’s disease. J Pharmacol Exp Ther 362: 413-423.

Waterhouse U, Brennan KE and Ellenbroek BA (2017) Nicotine self-administration reverses cognitive deficits in a rat model for schizophrenia. Addict Biol 23: 620 -630.

Sanchez JPB and Ellenbroek BA (2017) Preclinical effects of antipsychotic drugs. Curr Topics Behav Neurosci 34: 1 – 16.

Berrio J, Wang W and Ellenbroek BA (2017) Perspectives on the neurobiology of antipsychotic drugs in psychiatric disorders. OBM Neurobiology 1,(2017),e1 1: 1.

2016 Publications

Ellenbroek BA and Karl T (2016) Genetic rat models for schizophrenia. In Modelling Psychopathological Dimensions of Schizophrenia (Eds Pletnikov M and Waddington J), Elsevier, pp. 303-324.

Homberg JR, Olivier JDA, VandenBroeke M, Youn J, Ellenbroek AK, Karel P, Shan L, van Boxtel R, Ooms S, Balemans M, Langedijk J, Muller M, Vriend G, Cools AR, Cuppen E and Ellenbroek BA (2016) The role of the dopamine D1 receptor in social cognition: Studies using a novel genetic rat model. Dis Mod Mech 9: 1147-1158.

Waterhouse U, Roper VE, Brennan KE and Ellenbroek BA (2016) Nicotine ameliorates cognitive deficits induced by maternal LPS exposure: A study in rats. Dis Mod Mech 9: 1159-1167.

Ellenbroek BA, Angelucci F, Husum H and Mathe AA (2016) Gene – environment interactions in a rat model of depression. Maternal separation affects neurotensin in selected brain regions. Neuropeptides 59: 83-88.

Ellenbroek BA, August C and Youn J (2016) Does prenatal valproate interact with a genetic reduction in the serotonin transporter? A rat study on anxiety and cognition. Front Neurosci 10: e424.

Ellenbroek BA and Youn J (2016) Rodent models in neuroscience research: Is it a rat race? Dis Mod Mech 9: 1079-1087.

Ranger P and Ellenbroek BA (2016) Perinatal Influences of Valproate on Brain and Behaviour: An Animal Model for Autism. Curr Topics Behav Neurosci 29: 383-386.

Abada YK and Ellenbroek BA (2016) Of rodents and men: understanding the emergence of motor and cognitive symptoms in Huntington disease. Behav Pharmacol 7: 403-414

2015 Publications

Ellenbroek BA and Ghiabi B (2015) Do Histamine receptor 3 antagonists have a place in the therapy for schizophrenia? Curr Pharmaceutic Design 21: 3760-3770.

Ellenbroek BA and Prinssen EPM (2015) Can 5-HT3 antagonists contribute toward the treatment of schizophrenia? Behav Pharmacol 26: 33-44.

Ellenbroek BA (2015) Animal models of schizophrenia. In Encyclopaedia of psychopharmacology part 19 (Ed Stolerman I), Springer Verlag, Heidelberg, 2nd Edition pp.1-8 .

Ellenbroek BA and Karl T (2015) Genetic rat models for schizophrenia. In Modelling Psychopathological Dimensions of Schizophrenia (Eds Pletnikov M and Waddington J), Elsevier, pp 301-322.

Willner P, Bergman J, vanderSchuren L and Ellenbroek B (2015) The behavioural pharmacology of the basal ganglia: In memory of Lex Cools. Behav Pharmacol 25: 1-2.

Ellenbroek BA, Homberg J, Verheij M, Spooren W, van den Bos R and Martens G (2014) Alexander Rudolf Cools (1942-2013). Psychopharmacol 231: 2219-2222.

Willner P, Bergman J, vanderSchuren L and Ellenbroek B (2015) Pharmacological approaches to the study of social behaviour. Behav Pharmacol 26: 501-504.

2014 Publications

Ellenbroek BA & Ghiabi B (2014) The other side of the histamine H3 receptorTrends Neurosci 37: 191-199.

Oakly AC, Brox BW, Schenk S and Ellenbroek BA (2014) A genetic deletion of the serotonin transporter greatly enhances the reinforcing properties of MDMA in ratsMol Psychiatry 19: 534-535.

Ellenbroek BA and Cesura A (2014) Antipsychotics and the dopamine – serotonin connection. In Topics in Medicinal Chemistry (Eds Celanire S and Poli SM), Springer pp 1 – 49.

Willner P, Bergman J, vanderSchuren L and Ellenbroek B (2014) The behavioural pharmacology of stress Behav Pharmacol 25: 337-339.

2013 Publications

Abada, YS, Ngyuen HP, Schreiber RS and Ellenbroek BA (2013) Assessment of motor function, sensory motor gating and recognition memory in a novel BACHD transgenic rat model for Huntington diseasePLOS One 8(7), e68584.

Abada, YS, Nguyen HP, Ellenbroek BA and Schreiber RS (2013) Reversal learning and associative memory impairments in a BACHD rat model for Huntington diseasePLOS One (in press).

Abada, YS, Schreiber RS and Ellenbroek BA (2013) Motor, emotional and cognitive deficits in adult BACHD mice: A model for Huntington’s diseaseBehav Brain Res 238: 243-251.

Ellenbroek BA (2013) Histamine H3 receptors: The complex interaction with dopamine and its implications for addictionBr J Pharmacology 170: 46-57.

2012 Publications

Schellekens AFA, Mulders P, Ellenbroek B, de Jong C, Buitelaar K, Cools A and Verkes RJ (2012) Early-onset alcohol dependence increases the acoustic startle reflexAlcoholism: Clinical and Experimental Research 36: 574-582.

Schellekens AFA, Franke B, Ellenbroek BA, Cools A, De Jong CAJ, Buitelaar JK and Verkes RJ (2012) COMT Val158Met modulates the effect of childhood adverse experiences on the risk of alcohol dependenceAddiction Biology.

Schellekens AFA, Franke B, Ellenbroek BA, Cools A, De Jong CAJ, Buitelaar JK and Verkes RJ (2012) The COMT Val158Met and DRD2 Taq1A genotypes in alcohol dependence, reduced dopamine sensitivity as intermediate phenotypeArch Gen Psychiatr 69: 339-348.

Youn J, Ellenbroek BA, van Eck I, Roubos S, Verhage M and Stiedl O (2012) Finding the right motivation: Genotype-dependent differences in effective reinforcements for spatial learningBehav Brain Res 226: 397-403.

Ellenbroek BA (2012) Psychopharmacological treatment of schizophrenia: What do we have, and what could we get? Neuropharmacol 62: 1371-1380.

2010 Publications

Olivier JDA, Cools AR, Deen PMT, Olivier B and Ellenbroek BA (2010) Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters. Eur J Pharmacol 629: 7-11.

Molteni R, Cattaneo A, Calabrese F, Macchi F, Olivier JDA, Racagni G, Ellenbroek BA, Gennarelli M and Riva MA (2010) Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans. Neurobiol Dis 37: 747-755.

Mul JD, Yi CX, van den Berg SAA, Ruiter M, Toonen PM, van der Elst MCJ, Voshol PJ, Ellenbroek BA, Andries Kalsbeek A, la Fleur SE, and Cuppen E (2010) Pmch expression during early development is critical for normal energy homeostasis. Am J Physiol Endocrinol and Metabol 298:E477-88.

Calabrese F, Molteni R, Cattaneo A, Macchi F, Racagni G, Gennarelli M, Ellenbroek BA and Riva MA (2010) Chronic duloxetine treatment normalizes altered BDNF expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms. Mol Pharmacol 77: 846-853.

Olivier JDA, Cools AR, Ellenbroek BA, Cuppen E and Homberg JR (2010), Serotonin transporter knockout rats. In: Experimental models in serotonin transporter research (Ed. Kalueff AV and LaPorte JL), Cambridge Univ Press, Cambridge, pp.170-213.

Ellenbroek BA (2010) Schizophrenia. In Encyclopaedia of behavioural Neuroscience vol 3 (Eds. Koob G, Thompson RF and LeMoal M), Oxford Academic Press, Oxford, pp.188-195.

Ellenbroek BA (2010) Animal models of schizophrenia. In Encyclopaedia of psychopharmacology part 19 (Ed Stolerman I), Springer Verlag, Heidelberg, pp. 1181-1186.

2009 Selected Publications

Gemkow MJ, Davenport AJ, Harich S, Ellenbroek BA, Cesura A and Hallett D (2009) The histamine H3 receptor as a therapeutic drug target for CNS Drug Discov Today 14: 509-515

Olivier JDA, Jans L, Blokland A, Broers Nick, Homberg JR, Ellenbroek BA and Cools AR (2009) Serotonin transporter deficiency in rats contributes to impaired object memory. Genes Brain Behav 8: 829-834.

Fernandez-Espejo E, Viveros MP, Nunes L, Ellenbroek BA and Rodriguez de Fonseca F (2009) Role of cannabis and endocannabinoids in the genesis of schizophrenia. Psychopharmacology 206: 531-549.

Molteni R, Calabrese F, Maj PF, Olivier JDA, Racagni G, Ellenbroek BA and Riva MA (2009) Altered expression and modulation of activity-related cytoskeletal associated protein (Arc) in serotonin transporter knockout rats. Eur Neuropsychopharmacol 19: 898-904.

Schellekens AEA, Grootens KP, Neef C, Movig KLL, Buitelaar JK, Ellenbroek B and Verkes RJ (2009) Effect of apomorphine on cognitive performance and sensorimotor gating in humans. Psychopharmacol 207: 559-569.

Schellekens AEA, van Oosterwijck AWAA, Ellenbroek B, de Jong CAJ, Buitelaar JK, Cools L and Verkes RJ (2009) The dopamine agonist apomorphine differentially affects cognitive performance in alcohol dependent patients and healthy controls. Europ Neuropsychopharmacol 19: 68-73.

2008 Publications

Olivier JDA, van der Hart NGC, van Swelm RPL, Deeren PJ, Homberg JR, Cremers T, Deen PMT, Cuppen E, Cools AR and Ellenbroek BA (2008), A study in male and female 5-HT transporter knockout rats: An animal model for anxiety and depression disorders. Neuroscience 152: 573-584.

Olivier JDA, Jans LAW, Korte-Bouws GAH, Korte SM, Deen PMT, Cools AR, Ellenbroek BA and Blokland A (2008) Acute tryptophan depleting dose-dependently impairs object memory in serotonin transporter knockout rats. Psychopharmacology 200: 243-254.

Homberg JR, de Boer SF, Raaso HS, Olivier JDA, Verheul M, Ronken E, Cools AR, Ellenbroek BA, Schoffelmeer ANM, Vanderschuren LJMJ, de Vries TJ and Cuppen E (2008) Adaptations in pre- and postsynaptic 5-HT1A receptor function and cocaine supersensitivity in serotonin transporter knockout rats. Psychopharmacology 200: 367-380.

Olivier JDA, Cools AR, Olivier B, Homberg JR, Cuppen E and Ellenbroek BA (2008) Stress-induced hyperthermia and basal body temperature are mediated via different 5-HT1A receptor populations: A study in SERT knockout rats. Eur J Pharmacol 590: 190-197.

Ellenbroek BA (2008) The pharmacotherapy of schizophrenia: Past, present and possible future. In: Schizophrenia, sleep and acupuncture (Eds. Bosch P and van der Noort M), Hogrefe & Huber, Göttingen, pp.35-57.

Bosch P, Coenen AML, Ellenbroek BA and van der Noort M (2008) Acupuncture and sleep: Can acupuncture be used in the treatment of insomnia and schizophrenia? In: Schizophrenia, sleep and acupuncture (Eds. Bosch P and van der Noort M), Hogrefe & Huber, Göttingen, pp.249-262.